<i>Lactobacillus reuteri</i> attenuates cardiac injury without lowering cholesterol in low-density lipoprotein receptor-deficient mice fed standard chow
Matthew P. Koppinger, Marissa A. Lopez‐Pier, Rinku Skaria, Preston R. Harris, John P. Konhilas
Abstract
We demonstrated that daily delivery of Lactobacillus reuteri to wild-type and hypercholesterolemic lipoprotein receptor knockout mice attenuated cardiac injury following ischemia-reperfusion without lowering total serum cholesterol in the short term. In addition, we validated protection against cardiac injury using histology and immunohistochemistry techniques. L. reuteri offers promise as a probiotic to mitigate ischemic cardiac injury.
Topics & Concepts
Lactobacillus reuteriProbioticMedicineLDL receptorImmunohistochemistryMyocardial ischemiaKnockout mouseReceptorLipoproteinCholesterolIschemiaReperfusion injuryHistologyInternal medicinePharmacologyEndocrinologyCardiologyBiologyBacteriaGeneticsProbiotics and Fermented FoodsRNA and protein synthesis mechanismsProtein Hydrolysis and Bioactive Peptides