Synthesis of Phenolic Coumestans via a Sequential Dehydrogenation/Oxa-Michael Addition Reaction of 2′,4′-Dihydroxyl-3-arylcoumarins
Qinfang Yan, Yi Jiang, Xianheng Song, Guoqing Lu, Qianzhong Zhang, Zhibo Du, Albert S. C. Chan, Yong Zou
Abstract
A facile and practical approach for the synthesis of natural coumestans and derivatives starting from 2',4'-dihydroxyl-3-arylcoumarins has been developed. The process involved a seqential intramolecular dehydrogenation/oxa-Micheal reaction efficiently promoted by 1,8-diazabicyclo[5.4.0]undec-7-ene at 40 °C under metal- and ligand-free conditions with good functional group compatibility.
Topics & Concepts
DehydrogenationMichael reactionChemistryOrganic chemistryCatalysisSynthesis of Indole DerivativesBioactive natural compoundsGABA and Rice Research