Microglial A20 Protects the Brain from CD8 T-Cell-Mediated Immunopathology
Alma N. Mohebiany, Nishada Shakunty Ramphal, Khalad Karram, Giovanni Di Liberto, Tanja Novkovic, Matthias Klein, Fédérico Marini, Mario Kreutzfeldt, Franziska Härtner, Sonja M. Lacher, Tobias Bopp, Thomas Mittmann, Doron Merkler, Ari Waisman
Abstract
terminals and frequency of spontaneous excitatory currents. Ultimately, A20-deficient microglia upregulate genes associated with the antiviral response and neurodegenerative diseases. Together, our data suggest that microglial A20 acts as a sensor for viral infection and a master regulator of CNS homeostasis.
Topics & Concepts
MicrogliaImmune systemBiologyInflammationCD8ImmunologyRegulatorTumor necrosis factor alphaDownregulation and upregulationCytotoxic T cellCell biologyHomeostasisGeneBiochemistryIn vitroNeuroinflammation and Neurodegeneration MechanismsImmune Response and InflammationImmune cells in cancer