Calycosin enhances the bactericidal efficacy of polymyxin B by inhibiting MCR‐1 <i>in vitro</i>
Xiaoping Liu, Xiaodi Sun, Xu Deng, Xiaohua Lv, Jianfeng Wang
Abstract
AIM: To examine the synergistic effect of calycosin combined with polymyxin B against various mcr-1-positive bacterial strains. METHODS AND RESULTS: . CONCLUSIONS: Therefore, our results suggested that calycosin could be used as a potential MCR-1 inhibitor to restore the bactericidal effect of polymyxin B without affecting bacterial viability or existing cytotoxicity. SIGNIFICANCE AND IMPACT OF THE STUDY: The synergistic effect of calycosin combined with polymyxin B against various mcr-1-positive bacterial strains paves the way for future pharmaceutical applications of calycosin in fighting mcr-1-positive bacterial infections.
Topics & Concepts
CalycosinPolymyxin BPolymyxinCytotoxicityMicrobiologyMinimum inhibitory concentrationChemistryIn vitroPharmacologyBiologyBiochemistryAntibioticsFormononetinEndocrinologyDaidzeinGenisteinAntibiotic Resistance in BacteriaBacterial biofilms and quorum sensingAntimicrobial Resistance in Staphylococcus