Litcius/Paper detail

Chalcone derivatives as xanthine oxidase inhibitors: synthesis, binding mode investigation, biological evaluation, and ADMET prediction

Can Yang, Yi Liu, Yanbei Tu, Lizi Li, Jiana Du, Dehong Yu, Pei He, Tao Wang, Yan Liu, Hao Chen, Yanfang Li

2022Bioorganic Chemistry29 citationsDOI

Topics & Concepts

ChemistryHyperuricemiaXanthine oxidaseAllopurinolGoutStereochemistryIC50ChalconePotencyUric acidPharmacologyHypoxanthineFebuxostatSulfonamideXanthine oxidase inhibitorIn vitroBiochemistryEnzymePathologyMedicineGout, Hyperuricemia, Uric AcidPharmacological Effects of Natural CompoundsNatural product bioactivities and synthesis