Switchable photocatalysis for the chemodivergent benzylation of 4-cyanopyridines
Eleni Georgiou, Davide Spinnato, Kang Chen, Paolo Melchiorre, Kilian Muñiz
Abstract
radical coupling and a Minisci-type addition, enabled selective access to regioisomeric C4 or C2 benzylated pyridines, respectively. Mechanistic investigations shed light on the origin of the chemoselectivity switch.
Topics & Concepts
PhotocatalysisRadicalCatalysisChemistryPhotoredox catalysisAlkylPhotochemistryOrganic chemistryCombinatorial chemistryRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques