Recent Advances in the Development of Sigma Receptor Ligands as Cytotoxic Agents: A Medicinal Chemistry Perspective
Antonino N. Fallica, Valeria Pittalà, Maria Modica, Loredana Salerno, Giuseppe Romeo, Agostino Marrazzo, Mohamed A. Helal, Sebastiano Intagliata
Abstract
R ligands with antiproliferative and cytotoxic activities has been provided, including major pharmacophore models and comprehensive structure-activity relationships for each main class of σR ligands.
Topics & Concepts
PharmacophoreChemistryCytotoxic T cellReceptorSigma receptorPharmacologyComputational biologyBiochemistryStereochemistryIn vitroBiologyPharmacological Receptor Mechanisms and EffectsPhenothiazines and Benzothiazines Synthesis and ActivitiesReceptor Mechanisms and Signaling