Magnetic metal phenolic networks: expanding the application of a promising nanoprobe to phosphoproteomics research
Huimin Chu, Haoyang Zheng, Jizong Yao, Nianrong Sun, Guoquan Yan, Chunhui Deng
Abstract
A Ti-tannic acid modified magnetic nanoprobe was synthesized via one step, and applied to phosphopeptide extraction. 3456 phosphopeptides and 1285 phosphoproteins were finally identified from 100 μg HeLa cell extracts. This opens up a new avenue for metal phenolic networks in phosphoproteomics research.
Topics & Concepts
Tannic acidHeLaNanoprobePhosphoproteomicsNanotechnologyCombinatorial chemistryChemistryMetalMaterials scienceCellNanoparticleOrganic chemistryBiochemistryEnzymeProtein phosphorylationProtein kinase AAdvanced Proteomics Techniques and ApplicationsAdvanced Nanomaterials in CatalysisMetabolomics and Mass Spectrometry Studies