Genetic Diversity of HLA Class I and Class II Alleles in Thai Populations: Contribution to Genotype-Guided Therapeutics
Patompong Satapornpong, Pimonpan Jinda, Thawinee Jantararoungtong, Napatrupron Koomdee, Chonlawat Chaichan, Jirawat Pratoomwun, Chalitpon Na Nakorn, Wichai Aekplakorn, Alisa Wilantho, Chumpol Ngamphiw, Sissades Tongsima, Chonlaphat Sukasem
Abstract
Human leukocyte antigen (HLA) class I and II alleles encodes several molecules that play role in the human immune system. There were found the association of HLA alleles and drug-induced cutaneous adverse reactions. The aim of this study was to investigate HLA class I and II alleles distribution in five regions of Thailand and to explore the relation of pharmacogenetic markers. HLA-A, -B, –C, -DRB1, -DQA1 and –DQB1 of 470 unrelated individuals Thai population were performed by polymerase chain reaction sequence-specific oligonucleotides probe (PCR-SSOs). Most frequency of HLA alleles in Thai population, including of HLA-A*11:01 (26.06%), -B*46:01 (14.04%), -C* 01:02 (17.13%), -DRB1*12:02 (15.32%), -DQA1*01:01 (24.89%) and -DQB1*05:02 (21.28%). The distribution of pharmacogenetic markers were different between Thai and other populations (African Americans, Caucasians, Hispanics, North American and Asians) consist of HLA-B*15:02, -B*13:01, -A*24:02, -A*33:03, -C*08:01, -C*03:02, -DRB1*12:02, -DRB1*16:02, -DRB1*13:02, -DRB1*15:02 and –DQB1*06:02. This first study of HLA class I and II database in five regions of Thailand. In addition, the database of HLA class I and II distribution might be compared with other ethnicity and support pharmacogenetic markers for screening prior before culprit drug administration.