SPAAC iClick: progress towards a bioorthogonal reaction in-corporating metal ions
Yu-Hsuan Shen, Alec M. Esper, Ion Ghiviriga, Khalil A. Abboud, Kirk S. Schanze, Christian Ehm, Adam S. Veige
Abstract
Combining strain-promoted azide–alkyne cycloaddition (SPAAC) and inorganic click (iClick) reactivity provides access to metal 1,2,3-triazolates.
Topics & Concepts
Bioorthogonal chemistryCycloadditionReactivity (psychology)ChemistryAzideAlkyneClick chemistryCombinatorial chemistryMetalMetal ions in aqueous solutionIonOrganic chemistryCatalysisMedicineAlternative medicinePathologyClick Chemistry and ApplicationsChemical Synthesis and AnalysisBiotechnology and Related Fields