Structure–Activity Relationship Studies of α-Ketoamides as Inhibitors of the Phospholipase A and Acyltransferase Enzyme Family
Juan Zhou, Elliot D. Mock, Karol Al Ayed, Xinyu Di, Vasudev Kantae, Lindsey Burggraaff, Anna F. Stevens, Andrea Martella, Florian Mohr, Ming Jiang, Tom van der Wel, Tiemen J. Wendel, Tim P. Ofman, Yvonne Tran, Nicky de Koster, Gerard J. P. van Westen, Thomas Hankemeier, Mario van der Stelt
Abstract
may help to dissect the physiological role of the PLAATs.
Topics & Concepts
AnandamideChemistryArachidonic acidEnzymePhospholipase A2BiochemistryLipid signalingAcyltransferasePhospholipase AEnzyme inhibitorPhospholipaseStructure–activity relationshipIn vitroCannabinoid receptorReceptorAgonistCannabis and Cannabinoid ResearchPeroxisome Proliferator-Activated ReceptorsPancreatic function and diabetes