Immune-related adverse events and the balancing act of immunotherapy
Michael Conroy, Jarushka Naidoo
Abstract
The benefit from immune checkpoint inhibitors is tempered by immunologic toxicities, which involve diverse organs, have varying biology, onset time, and severity. Herein, we identify important areas of controversy and open research questions in the field of immune-related toxicity.
Topics & Concepts
Immune systemImmunotherapyImmunologyAdverse effectImmune checkpointMedicineBiologyBioinformaticsPharmacologyCancer Immunotherapy and BiomarkersImmune Cell Function and InteractionPARP inhibition in cancer therapy