Does methylprednisolone reduce the mortality risk in hospitalized COVID-19 patients? A meta-analysis of randomized control trials
Syed Shahzad Hasan, Chia Siang Kow, Zia Ul Mustafa, Hamid A. Merchant
Abstract
: In determining equipotent doses for an acute short-course pulse therapy of corticosteroids, the biological half-life of steroids should also be accounted for besides the potency factor. A short duration (3-5 days) pulse therapy of high-dose methylprednisolone can be a promising alternative to the low-dose dexamethasone therapy in severely ill patients with COVID-19 to prevent deaths.
Topics & Concepts
MedicineMethylprednisoloneRandomized controlled trialCoronavirus disease 2019 (COVID-19)DexamethasoneMeta-analysisIntensive care medicineDiseaseInternal medicineInfectious disease (medical specialty)COVID-19 Clinical Research StudiesLong-Term Effects of COVID-19Sepsis Diagnosis and Treatment