Highly-tumor-targeted PAD4 inhibitors with PBA modification inhibit tumors in vivo by specifically inhibiting the PAD4-H3cit-NETs pathway in neutrophils
Di Zhu, Lu Yu, Bo Hu, Yuheng Pang, Bingru Liu, Miao Zhang, Wenjing Wang, Yuji Wang
Topics & Concepts
In vivoChemistryCancer researchMetastasisIn vitroFlow cytometryTumor microenvironmentCancer cellCancerBiochemistryMolecular biologyBiologyInternal medicineMedicineTumor cellsBiotechnologyImmune cells in cancerS100 Proteins and AnnexinsNeutrophil, Myeloperoxidase and Oxidative Mechanisms