Bioinspired self-degradable hydrogels towards wound sealing
Qingchen Cao, Guofei Sun, Xing Wang, Fei Yang, Licheng Zhang, Decheng Wu
Abstract
Inspired by the autolysis of shaggy mane, we developed a self-degradable hydrogel as a medical adhesive for skin wounds. The rapid gelation and self-degradation of the hydrogel were achieved via the Michael addition and subsequent hydrolysis of the addition product. In vivo experiments further showed that the hydrogel adhesive was efficiently applied for skin wound repair.
Topics & Concepts
Self-healing hydrogelsHydrolytic degradationAdhesiveChemistryHydrolysisSelf-healingWound healingSelf adhesivePolymer chemistryPolymer scienceOrganic chemistrySurgeryAlternative medicineLayer (electronics)PathologyMedicineHydrogels: synthesis, properties, applicationsElectrospun Nanofibers in Biomedical ApplicationsPolymer Surface Interaction Studies