Dietary supplementation of clinically utilized PI3K p110α inhibitor extends the lifespan of male and female mice
Christopher P. Hedges, Bhoopika Shetty, Sophie C. Broome, Caitlin MacRae, Parisa Koutsifeli, Emma J. Buckels, C. Macindoe, Jordi Boix, T. Tsiloulis, Brya G. Matthews, Sunita Sinha, Michael Arendse, Jagdish K. Jaiswal, Kimberley M. Mellor, Anthony J. Hickey, Peter R. Shepherd, Troy L. Merry
Topics & Concepts
LongevityInsulin-like growth factor 1 receptorInsulin receptorInsulinEndocrinologyInsulin-like growth factorReceptorPI3K/AKT/mTOR pathwayInternal medicineBiologyGrowth factorTranslation (biology)MedicineSignal transductionCell biologyInsulin resistanceGeneticsMessenger RNAGeneGenetics, Aging, and Longevity in Model OrganismsDietary Effects on HealthFOXO transcription factor regulation