Successful Development of Bacteriocins into Therapeutic Formulation for Treatment of MRSA Skin Infection in a Murine Model
Kirill V. Ovchinnikov, Christian Kranjec, Tage Thorstensen, Harald Carlsen, Dzung B. Diep
Abstract
The emergence of antibiotic-resistant pathogens has caused a serious worldwide problem in infection treatment in recent years. One of the pathogens is methicillin-resistant Staphylococcus aureus (MRSA), which is a major cause of skin and soft tissue infections. Alternative strategies and novel sources of antimicrobials to solve antibiotic resistance problems are urgently needed. In this study, we explored the potential of two broad-spectrum bacteriocins, garvicin KS and micrococcin P1, in skin infection treatments.
Topics & Concepts
Staphylococcus aureusBacteriocinMethicillin-resistant Staphylococcus aureusMedicineAntibioticsAnti-Infective AgentsMicrobiologyStaphylococcal infectionsAntibacterial agentSkin infectionIntensive care medicineBiologyBacteriaAntimicrobialGeneticsAntimicrobial Resistance in StaphylococcusAntimicrobial Peptides and ActivitiesFungal Infections and Studies