Temporal increase in D614G mutation of SARS-CoV-2 in the Middle East and North Africa
Malik Sallam, Nidaa A. Ababneh, Deema Dababseh, Faris G. Bakri, Azmi Mahafzah
Abstract
BACKGROUND: gene sequences phylogenetically. METHODS: gene sequences collected in the MENA were retrieved from the GISAID public database, together with its metadata. Mutation analysis was conducted in Molecular Evolutionary Genetics Analysis software. Phylogenetic analysis was done using maximum likelihood (ML) and Bayesian methods. RESULT: substitutions/site/year based on large clusters' Bayesian analyses. CONCLUSIONS: The D614G mutation appeared to be taking over the COVID-19 infections in the MENA. Bayesian analysis suggested that SARS-CoV-2 might have been circulating in MENA earlier than previously reported.
Topics & Concepts
Phylogenetic treeMutationBiologyGeneticsGeneMutation rateEvolutionary biologySARS-CoV-2 and COVID-19 Researchvaccines and immunoinformatics approachesMosquito-borne diseases and control