Litcius/Paper detail

PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program

Masao Hashimoto, Koichi Araki, Maria A. Cardenas, Peng Li, Rohit R. Jadhav, Haydn Kissick, William Henry Hudson, Donald J. McGuire, Rebecca C. Obeng, Andreas Wieland, Judong Lee, Daniel T. McManus, James Ross, Se Jin Im, Junghwa Lee, Jian‐Xin Lin, Bin Hu, Erin E. West, Christopher D. Scharer, Gordon J. Freeman, Arlene H. Sharpe, Suresh S. Ramalingam, Alex Pellerin, Volker Teichgräber, William J. Greenleaf, Christian Klein, Jörg J. Goronzy, Pablo Umaña, Warren J. Leonard, Kendall A. Smith, Rafi Ahmed

2022Nature322 citationsDOIOpen Access PDF

Topics & Concepts

Lymphocytic choriomeningitisIL-2 receptorCD8Cytotoxic T cellBlockadeEffectorBiologyInterleukin 21CytokineCell biologyImmunologyT cellCancer researchReceptorImmune systemBiochemistryIn vitroImmune Cell Function and InteractionCAR-T cell therapy researchImmunotherapy and Immune Responses