Sirt6 deficiency aggravates angiotensin II-induced cholesterol accumulation and injury in podocytes
Qian Yang, Jijia Hu, Yingjie Yang, Zhaowei Chen, Jun Feng, Zijing Zhu, Huiming Wang, Dingping Yang, Wei Liang, Guohua Ding
Abstract
These findings provide evidence that Sirt6 is a potential target for renin-angiotensin system (RAS)-associated podocyte injury and provide a rationale for the application of cholesterol-lowering agents in patients with CKD.
Topics & Concepts
PodocyteGlomerulosclerosisEndocrinologyInternal medicineCholesterolAngiotensin IIRenin–angiotensin systemKidneyKidney diseasePitavastatinMedicineNephropathyChemistryStatinDiabetes mellitusProteinuriaReceptorBlood pressureRenal Diseases and GlomerulopathiesHormonal Regulation and HypertensionCholesterol and Lipid Metabolism