Epigenetic profiling reveals a subset of pediatric-type glioneuronal tumors characterized by oncogenic gene fusions involving several targetable kinases
Philipp Sievers, Martin Sill, Daniel Schrimpf, Dennis Friedel, Dominik Sturm, Maria Gardberg, Kathreena M. Kurian, Lenka Krsková, Aleš Vícha, Tina Schaller, Christian Hagel, Zied Abdullaev, Kenneth Aldape, Thomas S. Jacques, Andrey Korshunov, Wolfgang Wick, Stefan M. Pfister, Andreas von Deimling, David Jones, Felix Sahm
Abstract
Glioneuronal tumors (GNTs) are a diverse group of central nervous system (CNS) neoplasms that primarily affects children and young adults Their histopathological diagnosis can be extremely challenging due to overlapping morphological features among the different (sub-)types. In recent years, the use of next-generation sequencing and DNA methylation arrays revealed a large spectrum of different types of GNTs that are often characterized by a unique