Design, step-economical diversity-oriented synthesis of an N-heterocyclic library containing a pyrimidine moiety: discovery of novel potential herbicidal agents
Dong Ma, Yin Yang, Ying-Lu Chen, Yitao Yan, Jun Wu
Abstract
at 750 g ai per ha. More importantly, pyrimidine-tetrahydrocarbazole hybrid 5q showed good to excellent herbicidal activity against five test weeds at the same dosage. Pyrimidine-tetrahydrocarbazole hybrids represent a novel class of herbicidal agents that may become promising lead compounds in the herbicidal discovery process.
Topics & Concepts
MoietyPyrimidineCombinatorial chemistryChemistryDrug discoveryStereochemistryBiochemistrySynthesis and Biological EvaluationQuinazolinone synthesis and applicationsChemical Synthesis and Analysis