Arresting metastasis within the microcirculation
Angelos Varotsos Vrynas, Julia Perea Paizal, Chris Bakal, Sam H. Au
Abstract
The behaviour of circulating tumour cells in the microcirculation remains poorly understood. Growing evidence suggests that biomechanical adaptations and interactions with blood components, i.e. immune cells and platelets within capillary beds, may add more complexity to CTCs journey towards metastasis. Revisiting how these mediators impact the ability of circulating tumour cells to survive and metastasise, will be vital to understand the role of microcirculation and advance our knowledge on metastasis.
Topics & Concepts
MicrocirculationMetastasisHematologySurgical oncologyAngiogenesisImmune systemPathologyBiologyMedicineImmunologyCancerCancer researchInternal medicineCancer Cells and MetastasisBlood transfusion and managementCancer Genomics and Diagnostics