In Situ Alkyl Radical Recycling-Driven Decoupled Electrophotochemical Deamination
Kui Wang, Xiaoyu Liu, Siyu Yang, Yan Tian, Mingyang Zhou, Jianhua Zhou, Xiaofei Jia, Baoying Li, Siyuan Liu, Jianbin Chen
Abstract
Molecular electrophotocatalysis has emerged as a powerful strategy for the development of sustainable synthetic protocols. With the proof-of-concept, we exploited a versatile electrophotocatalytic deaminative alkylation approach. Mechanistic investigation indicated that in situ recycling of the alkyl radicals was the key point. Notably, ligand modification and late-stage functionalization of pharmaceuticals were also established, highlighting its feasibility in practical utilization.
Topics & Concepts
ChemistryDeaminationAlkylAlkylationCombinatorial chemistryRadicalIn situSurface modificationOrganic chemistryCatalysisPhysical chemistryEnzymeRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques