S-adenosylmethionine-dependent methyltransferase inhibitor DZNep blocks transcription and translation of SARS-CoV-2 genome with a low tendency to select for drug-resistant viral variants
Ram Kumar, Nitin Khandelwal, Yogesh Chander, Himanshu Nagori, Assim Verma, Aditya Barua, Bhagraj Godara, Yash Pal, Baldev R. Gulati, Bhupendra Nath Tripathi, Sanjay Barua, Naveen Kumar
Topics & Concepts
BiologyRNACoronaviridaeRibonucleoproteinTranscription (linguistics)VirologyMethylationMethyltransferaseViral life cycleRNA-binding proteinProtein biosynthesisViral replicationMolecular biologyGeneticsVirusDNAGeneCoronavirus disease 2019 (COVID-19)MedicineLinguisticsInfectious disease (medical specialty)DiseasePhilosophyPathologyRNA modifications and cancerCancer-related molecular mechanisms researchCancer-related gene regulation