Discovery of Small Molecules That Target the Phosphatidylinositol (3,4,5) Trisphosphate (PIP3)-Dependent Rac Exchanger 1 (P-Rex1) PIP3-Binding Site and Inhibit P-Rex1–Dependent Functions in Neutrophils
Jennifer N. Cash, Naincy R. Chandan, Alan Y. Hsu, Prateek Sharma, Qing Deng, Alan V. Smrcka, J.J.G. Tesmer
Topics & Concepts
Pleckstrin homology domainGuanine nucleotide exchange factorPhosphatidylinositolChemistryBiochemistrySignal transductionBiologyCell biologyProtein Kinase Regulation and GTPase SignalingCell death mechanisms and regulationNeutrophil, Myeloperoxidase and Oxidative Mechanisms