Greener and whiter analytical method development and validation for determining the presence of zolpidem tartrate infused in apple juice using RP-HPLC <i>via</i> magnetic solid-phase extraction followed by LC-MS confirmatory analysis
Revathy Sundara Moorthy, G. Swetha, Rohini Rondla, Anren Hu, Narmada Vallakeerthi, P. Muralidhar Reddy
Abstract
nanoparticles was also assessed. To determine the sustainability of the proposed work, a greener and whiter assessment has been carried out in a comparative mode with previous similar works. For green tools, the recently developed AGREE software was utilized for assessing the method's greeness and it demonstrated a good green score of 0.68, supported by method assessment using ComplexGAPI software. For the assessment of the method's blue principles, the latest software utilizing the blue applicability grade index (BAGI) was applied, resulting in a decent score of 62.5. To consider sustainability, the RGB methodical software in its latest version the RGBfast model, was incorporated in the study for furnishing a balance of the three different major principles (Red-Green-Blue) and for assessing a check on sustainability of the current method compared to similar previously established proposed works.