Tumor identification <i>via in vivo</i> portable Raman detection of sialic acid with a dual gold nanoprobe system
Yuru Wang, Yuanjiao Yang, Jingxing Guo, Huangxian Ju, Yunlong Chen
Abstract
detection of SA, Au10-DTTC/PEG-PBA and Au40-PEG-SA were subsequently injected into tumor xenografted mice with optimal interval and retention times. Through the specific recognition between PBA and SA, the conjugates of Au10-DTTC/PEG-PBA and Au40-PEG-SA formed in the tumor region emitted strong SERS signals of DTTC, which could be detected by a portable Raman detector. This work provides a convenient and portable method to detect SA in tumor xenografted mice, which is useful for family-stay identification and clinical cleavage of tumors.
Topics & Concepts
NanoprobeIn vivoIdentification (biology)Sialic acidRaman spectroscopyChemistryDual (grammatical number)Computational biologyNanotechnologyBiochemistryMaterials scienceBiologyPhysicsGeneticsOpticsArtNanoparticleLiteratureBotanyAdvanced biosensing and bioanalysis techniquesBiosensors and Analytical DetectionSpectroscopy Techniques in Biomedical and Chemical Research