Genetic variations in the CTLA-4 immune checkpoint pathway are associated with colon cancer risk, prognosis, and immune infiltration via regulation of IQCB1 expression
Shuai Ben, Qiuyuan Zhu, Silu Chen, Shuwei Li, Mulong Du, Junyi Xin, Haiyan Chu, Zhengdong Zhang, Meilin Wang
Topics & Concepts
Colorectal cancerImmune systemImmune checkpointSingle-nucleotide polymorphismCytotoxic T cellAlleleCancer researchExpression quantitative trait lociOncologyImmunologyMedicineCancerBiologyImmunotherapyInternal medicineGeneGenotypeGeneticsIn vitroCancer Immunotherapy and BiomarkersGenetic factors in colorectal cancerImmune Cell Function and Interaction