Litcius/Paper detail

CHD1 loss reprograms SREBP2-driven cholesterol synthesis to fuel androgen-responsive growth and castration resistance in SPOP-mutated prostate tumors

Feiyu Chen, Haoyan Li, Yin Wang, Ximing Tang, Kevin Lin, Qidong Li, Chenling Meng, Wei Shi, Javier Leo, Xin Liang, Jie Zhang, Vivien Van, Iqbal Mahmud, Bo Wei, Philip L. Lorenzi, Maria Gabriela Raso, Ana M. Aparicio, Yue Lu, Daniel E. Frigo, Boyi Gan, Di Zhao

2025Nature Cancer10 citationsDOIOpen Access PDF

Topics & Concepts

CastrationAndrogenProstateInternal medicineCancer researchBiologyMedicineCancerHormoneProstate Cancer Treatment and ResearchUbiquitin and proteasome pathwaysCancer, Lipids, and Metabolism