Biocatalytic Synthesis of Moclobemide Using the Amide Bond Synthetase McbA Coupled with an ATP Recycling System
Mark Petchey, Benjamin Rowlinson, Richard C. Lloyd, Ian J. S. Fairlamb, Gideon Grogan
Abstract
PPK in the presence of polyphosphoric acid and 0.1 equiv of ATP, required for recycling of the cofactor.
Topics & Concepts
ChemistryAmideAmine gas treatingCarboxylic acidPeptide bondAmidaseSubstrate (aquarium)Organic chemistryNucleophileCombinatorial chemistryCatalysisEnzymeOceanographyGeologyChemical Synthesis and AnalysisMicrobial Natural Products and BiosynthesisEnzyme Catalysis and Immobilization