Hormetic modulation of angiogenic factors by exercise-induced mechanical and metabolic stress in human skeletal muscle
Matteo Fiorenza, Lasse Gliemann, Nina Brandt, Jens Bangsbo
Abstract
Skeletal muscle capillary growth is orchestrated by angiogenic factors sensitive to mechanical and metabolic signals. In this study, we employed an integrative exercise model to synergistically target, yet to different extents and for different durations, the mechanical and metabolic components of muscle activity that promote angiogenesis. Our results suggest that the magnitude of the myocellular perturbations incurred during exercise determines the amplitude of the angiogenic molecular signals, implying hormetic modulation of skeletal muscle angiogenesis by exercise-induced mechanical and metabolic stress.
Topics & Concepts
HormesisSkeletal muscleModulation (music)Internal medicineStress (linguistics)EndocrinologyMedicineOxidative stressPhysicsAcousticsLinguisticsPhilosophyAdipose Tissue and MetabolismExercise and Physiological ResponsesCardiovascular and exercise physiology