Reduction of DHHC5-mediated beclin 1 S-palmitoylation underlies autophagy decline in aging
Rui Guo, Jianping Liu, Xia Min, Wen Zeng, Bing Shan, Mengmeng Zhang, Zhuohao He, Yaoyang Zhang, Kaiwen He, Junying Yuan, Daichao Xu
Topics & Concepts
AutophagyPalmitoylationCell biologyNeurodegenerationBiologyMechanistic target of rapamycinKinasePhosphorylationPhosphatidylinositolULK1PI3K/AKT/mTOR pathwayProtein kinase ASignal transductionBiochemistryApoptosisDiseaseMedicineCysteineAMPKEnzymePathologyAutophagy in Disease and TherapyAlzheimer's disease research and treatmentsEndoplasmic Reticulum Stress and Disease