Design, synthesis, biological evaluation, and docking studies of novel triazolo[4,3-<i>b</i>]pyridazine derivatives as dual c-Met/Pim-1 potential inhibitors with antitumor activity
Mohamed E. Mahmoud, Eman Ahmed, Hamdy M. Ragab, Rania Farag A. El‐Telbany, Rasha A. Hassan
Abstract
-mTOR compared to staurosporine. Later, analysis of 4g showed good drug-ability and pharmacokinetic properties. A similar mode of interaction at the ATP-binding site of c-Met and Pim-1 compared to the docked ligands was suggested by additional docking studies of compound 4g.
Topics & Concepts
PyridazineDocking (animal)ChemistryStereochemistryCombinatorial chemistryNursingMedicineCancer Mechanisms and TherapySynthesis and bioactivity of alkaloidsSynthesis and biological activity