<i>Ehrlichia</i> SLiM Ligand Mimetic Activates Notch Signaling in Human Monocytes
LaNisha L. Patterson, Thangam S. Velayutham, Caitlan D. Byerly, Duc‐Cuong Bui, Jignesh Patel, Veljko Veljković, Slobodan Paessler, Jere W. McBride
Abstract
E. chaffeensis infects and replicates in mononuclear phagocytes, but how it evades innate immune defenses of this indispensable primary innate immune cell is not well understood. This investigation revealed the molecular details of a ligand mimicry cellular reprogramming strategy that involved a short linear motif (SLiM), which enabled E. chaffeensis to exploit host cell signaling to establish and maintain infection. E. chaffeensis TRP120 is a moonlighting effector that has been associated with cellular activation and other functions, including ubiquitin ligase activity.
Topics & Concepts
Ehrlichia chaffeensisInnate immune systemEffectorBiologyCell biologyMolecular mimicryImmune systemReprogrammingUbiquitin ligaseUbiquitinImmunologyCellVirologyGeneticsEhrlichiaGeneTickInvertebrate Immune Response MechanismsEchinoderm biology and ecologyAntimicrobial Peptides and Activities