In vivo cytosolic H<sub>2</sub>O<sub>2</sub> changes and Ca<sup>2+</sup> homeostasis in mouse skeletal muscle
Ryotaro Kano, Ayaka Tabuchi, Yoshinori Tanaka, Hideki Shirakawa, Daisuke Hoshino, David C. Poole, Yutaka Kano
2023American Journal of Physiology-Regulatory, Integrative and Comparative Physiology13 citationsDOI
Abstract
We developed an in vivo mouse myocyte H 2 O 2 imaging model during exogenous H 2 O 2 loading, ischemic hypoxia induced by cardiac arrest, and muscle contractions. In this study, the interrelationship between cytosolic H 2 O 2 levels and Ca 2+ homeostasis during muscle contraction and hypoxic conditions was revealed. These results contribute to the elucidation of the mechanisms of muscle fatigue and exercise adaptation.
Topics & Concepts
HomeostasisCytosolSkeletal muscleIn vivoMyocyteChemistryHypoxia (environmental)Contraction (grammar)Internal medicineEndocrinologyMuscle contractionCell biologyBiologyBiochemistryMedicineEnzymeOxygenBiotechnologyOrganic chemistryExercise and Physiological ResponsesCardiovascular and exercise physiologyAdipose Tissue and Metabolism