Visible-light-promoted acyl radical cascade reaction for accessing acylated isoquinoline-1,3(2<i>H</i>,4<i>H</i>)-dione derivatives
Yingpeng Su, Rong Zhang, Wenxuan Xue, Xuan Liu, Ya‐Nan Zhao, Ke‐Hu Wang, Danfeng Huang, Congde Huo, Yulai Hu
Abstract
A visible-light-promoted decarboxylative acyl radical acylation/cyclization cascade reaction of N-methacryloylbenzamides for accessing acylated isoquinoline-1,3(2H,4H)-dione derivatives was described. In this report, α-keto acids were used for generating acyl radicals and inducing radical acylations. This protocol features mild reaction conditions, operational practicality and a broad substrate scope.
Topics & Concepts
ChemistryIsoquinolineCascadeCascade reactionStereochemistryAcylationVisible spectrumCombinatorial chemistryOrganic chemistryCatalysisOptoelectronicsChromatographyPhysicsRadical Photochemical ReactionsOxidative Organic Chemistry ReactionsCatalytic C–H Functionalization Methods