Inoculum at the time of SARS-CoV-2 exposure and risk of disease severity
María Pilar Guallar, Rosa Meiriño, Carolina Donat‐Vargas, Octavio Corral, Nicolás Jouvé, Vicente Soriano
Abstract
A relationship between the infecting dose and the risk of disease severity has not been demonstrated for SARS-CoV-2 infection. Here, we report three clusters of individuals that were potentially exposed to distinct inoculum in Madrid. Overall each group developed divergent clinical forms of COVID-19. Our data support that a greater viral inoculum at the time of SARS-CoV-2 exposure might determine a higher risk of severe COVID-19.
Topics & Concepts
Coronavirus disease 2019 (COVID-19)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Disease2019-20 coronavirus outbreakMedicineBetacoronavirusSeverity of illnessVirologyInternal medicineInfectious disease (medical specialty)OutbreakSARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesSARS-CoV-2 detection and testing