Rationalizing the Role of Monosodium Glutamate in the Protein Aggregation Through Biophysical Approaches: Potential Impact on Neurodegeneration
Ishfaq Ahmad Ahanger, Sania Bashir, Zahoor Ahmad Parray, Mohamed F. Alajmi, Afzal Hussain, Faizan Ahmad, Md. Imtaiyaz Hassan, Asimul Islam, Anurag Sharma
Abstract
) is largely negative, suggesting the spontaneous nature of the interaction. Furthermore, even a low concentration of MSG is involved in the unfolding of the secondary structure of protein with the disappearance of original peaks and the formation of a unique peak in the far-UV CD, which is an attention-grabbing observation. This is the first investigation which links the dietary MSG with protein aggregation and thus will be very instrumental in understanding the mechanism of various MSG-related human physiological as well as neurological diseases.
Topics & Concepts
Monosodium glutamateProtein aggregationBiophysicsNeurodegenerationGlutamate receptorChemistryNucleationMechanism (biology)PolymerizationBiochemistryBiologyMedicineInternal medicineFood sciencePolymerPhysicsOrganic chemistryQuantum mechanicsDiseaseReceptorBiochemical Analysis and Sensing TechniquesLipid Membrane Structure and BehaviorNeuroscience and Neuropharmacology Research