Scalable Electrochemical Transition‐Metal‐Free Dehydrogenative Cross‐Coupling Amination Enabled Alkaloid Clausines Synthesis
Pan Zhang, Baoying Li, Liwei Niu, Ling Wang, Guofeng Zhang, Xiaofei Jia, Guoying Zhang, Siyuan Liu, Li Ma, Wei Gao, Dawei Qin, Jianbin Chen
Abstract
Abstract Reported herein is an environmentally benign electrochemical C−H bond dehydrogenative amination protocol for the construction of privileged carbazole moiety with broad generality. Preliminary mechanistic investigations implied a radical reaction pathway. Compared with traditional ionic routes, the scalable transition‐metal and exogenous‐oxidant free strategy highlighted the green and sustainable nature of this method. magnified image
Topics & Concepts
ChemistryAminationMoietyTransition metalCombinatorial chemistryElectrochemistryCarbazoleIonic bondingNanotechnologyOrganic chemistryCatalysisIonMaterials scienceElectrodePhysical chemistryRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques