N-(6-phenylpyridazin-3-yl)benzenesulfonamides as highly potent, brain-permeable, and orally active kynurenine monooxygenase inhibitors
Hidenori Kimura, Hitoshi Suda, Momoe Kassai, Mika Endo, Yoko Deai, Masahiro Yahata, Mari Miyajima, Yoshiaki Isobe
Topics & Concepts
KynurenineKynurenic acidKynurenine pathwayNeuroprotectionChemistryPharmacologyMPTPInternal medicineDiseaseParkinson's diseaseBiochemistryMedicineTryptophanAmino acidGenetic Neurodegenerative DiseasesTryptophan and brain disordersNeurological disorders and treatments