Electrochemical Decarboxylative Elimination of Carboxylic Acids to Alkenes
Jiage Yu, Teng Liu, Wanhao Sun, Yunfei Zhang
Abstract
An electrochemical strategy for the decarboxylative elimination of carboxylic acids to alkenes at room temperature has been developed. This mild and oxidant-free method provides a green alternative to traditional thermal decarboxylation reactions. Structurally diverse aliphatic carboxylic acids, including biologically active drugs, underwent smooth conversion to the corresponding alkenes in good to excellent yields.
Topics & Concepts
DecarboxylationChemistryElectrochemistryCarboxylic acidOrganic chemistryCombinatorial chemistryCatalysisElectrodePhysical chemistryRadical Photochemical ReactionsFluorine in Organic ChemistryOxidative Organic Chemistry Reactions