Osteosarcoma Pathogenesis Leads the Way to New Target Treatments
Isabel Fernandes, Cecília Melo-Alvim, Raquel Lopes-Brás, Miguel Esperança‐Martins, Luís Lopes-da-Costa
Abstract
Osteosarcoma (OS) is a rare condition with very poor prognosis in a metastatic setting. Basic research has enabled a better understanding of OS pathogenesis and the discovery of new potential therapeutic targets. Phase I and II clinical trials are already ongoing, with some promising results for these patients. This article reviews OS pathogenesis and new potential therapeutic targets.
Topics & Concepts
PathogenesisOsteosarcomaMedicineClinical trialBioinformaticsCancer researchBiologyImmunologyPathologySarcoma Diagnosis and TreatmentBone Tumor Diagnosis and TreatmentsCancer-related molecular mechanisms research