Multiomics reveal human umbilical cord mesenchymal stem cells improving acute lung injury <i>via</i> the lung-gut axis
Lu Lv, Enhai Cui, Bin Wang, Liqin Li, Feng Hua, Huadong Lu, Na Chen, Wenyan Chen
Abstract
BACKGROUND: the lung-gut microflora. AIM: To explore the effects of HUC-MSCs on lipopolysaccharide (LPS)-induced ALI in mice and the involvement of the lung-gut axis in this process. METHODS: -test, Wilcoxon rank-sum test, and Pearson correlation analysis were used for statistical analyses. RESULTS: genera appeared in both feces and BALF. Moreover, this study performed metabolomic analysis on the lung tissue and identified five upregulated metabolites and 11 downregulated metabolites in the LPS + MSC group compared to the LPS group, which were related to the purine metabolism and the taste transduction signaling pathways. Therefore, an intrinsic link between lung metabolite levels and BALF flora homeostasis was established. CONCLUSION: This study suggests that HUM-MSCs attenuate ALI by redefining the gut and lung microbiota.