PML Body Component Sp100A Is a Cytosolic Responder to IFN and Activator of Antiviral ISGs
Hongchang Dong, Wencheng Wu, Jingjing Li, Yilei Ma, Xiaomei Deng, Deyin Guo, Pei Xu
Abstract
PML bodies sit at the center stage of various important biological processes; however, the signal transduction networks of these macromolecular protein complexes remain enigmatic. The present study illustrates, in detail and for the first time, the course of signal receiving, processing, and implementation by PML bodies in response to IFN and virus infection.
Topics & Concepts
Cell biologyBiologyInterferonKinaseTranscription factorSignal transductionVirologyGeneticsGeneinterferon and immune responsesRetinoids in leukemia and cellular processesRNA regulation and disease