Synthesis, spectroscopic characterization and antimicrobial studies of Mn(II), Co(II), Ni(II), Cr(III) and Fe(III) melatonin drug complexes
Gaber O. Moustafa, Asma S. Al‐Wasidi, Ahmed M. Naglah, Moamen S. Refat, Samy M. El‐Megharbel, Atef Kalmouch
Abstract
Synthesis and characterizations of new Mn(II), Co(II), Ni(II), Cr(III) and Fe(III) melatonin drug complexes have been studied. The melatonin ligand act as a monodentate ligand through nitrogen of the deprotonated –NH pyrrole ring. This was confirmed by infrared spectra and microanalytical analysis. The magnetic moments data approved the complexity of Mn(II), Co(III), Ni(III) as a square planar and Cr(III), Fe(III) as an octahedral geometry, respectively. The biological activity of the melatonin free ligand is lower than that of the respected metal complexes. Thus, this indicates that the complexity is more effective than the antimicrobial activities of melatonin ligand.