Structure guided generation of thieno[3,2-<i>d</i>]pyrimidin-4-amine <i>Mycobacterium tuberculosis bd</i> oxidase inhibitors
Sarah M. Hopfner, Bei Shi Lee, Nitin Pal Kalia, Marvin J. Miller, Kévin Pethe, Garrett C. Moraski
Abstract
Screening for inhibitors of Cyt-<italic>bd</italic> in <italic>Mycobacterium bovis</italic> BCG and <italic>Mycobacterium tuberculosis</italic> revealed thieno[3,2-<italic>d</italic>]pyrimidine (<bold>7</bold>) which through SAR efforts resulted in an improved analogue (<bold>19</bold>) of this scaffold.
Topics & Concepts
Mycobacterium tuberculosisMycobacterium bovisContext (archaeology)ChemistryTuberculosisIC50MycobacteriumMicrobiologyBiochemistryBiologyIn vitroMedicinePaleontologyPathologyTuberculosis Research and EpidemiologyMycobacterium research and diagnosisCancer therapeutics and mechanisms