Programming cell communications with pH-responsive DNA nanodevices
Junjun Hou, Shitai Zhu, Ziwei Zhao, Jianlei Shen, Jie Chao, Jiye Shi, Jiang Li, Lihua Wang, Zhilei Ge, Qian Li
Abstract
DNA nanoswitches on cell surfaces could respond to changes of pH under physiological conditions by switching from a three-chain structure to a double-chain structure, thus connecting another set of cells modified with complementary single-stranded DNA. This pH-triggered cell communication offers a promising approach for cell-based therapy under a tumor microenvironment.
Topics & Concepts
DNANanotechnologyCellChemistryComputer scienceBiophysicsCell biologyMaterials scienceBiologyBiochemistryAdvanced biosensing and bioanalysis techniquesRNA Interference and Gene DeliveryMicro and Nano Robotics