Differential recognition of oligomannose isomers by glycan-binding proteins involved in innate and adaptive immunity
Chao Gao, Kathrin Stavenhagen, Barbara Eckmair, Tanya R. McKitrick, Akul Y. Mehta, Yasuyuki Matsumoto, Alyssa M. McQuillan, Melinda S. Hanes, Deniz Eriş, Kelly J. Baker, Nan Jia, Mohui Wei, Jamie Heimburg‐Molinaro, Beat Ernst, Richard D. Cummings
Abstract
-acetylglucosamine-1-phosphotransferase, and the bacterial adhesin FimH. The results demonstrate that each protein exhibits a unique specificity to oligomannose motifs and suggest the potential to rationally design inhibitors to selectively block these protein-glycan interactions.
Topics & Concepts
GlycanInnate immune systemAcquired immune systemImmunityGlycoproteinImmunologyBiologyDifferential (mechanical device)Computational biologyImmune systemBiochemistryAerospace engineeringEngineeringGlycosylation and Glycoproteins ResearchCarbohydrate Chemistry and SynthesisImmune Cell Function and Interaction