Epidemic Territorial Spread of IncP-2-Type VIM-2 Carbapenemase-Encoding Megaplasmids in Nosocomial Pseudomonas aeruginosa Populations
Paweł Urbanowicz, Ibrahim Bitar, Radosław Izdebski, Anna Baraniak, Elżbieta Literacka, Jaroslav Hrabák, Marek Gniadkowski
Abstract
In 2003 to 2004, the first five VIM-2 metallo-β-lactamase (MBL)-producing Pseudomonas aeruginosa (MPPA) isolates with an In4-like integron, In461 ( aadB - bla VIM-2 - aadA6 ), on conjugative plasmids were identified in three hospitals in Poland. In 2005 to 2015, MPPA expanded much in the country, and as many as 80 isolates in a collection of 454 MPPA (∼18%) had In461, one of the two most common MBL-encoding integrons.
Topics & Concepts
Pseudomonas aeruginosaIntegronBiologyMicrobiologyPlasmidCephalosporinGeneticsGeneBacteriaAntibioticsAntibiotic Resistance in BacteriaAntibiotic Use and ResistanceVibrio bacteria research studies